Mobile genetic elements – mechanism and consequences of transposition

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dc.contributor.author Wędrowski, Mateusz
dc.contributor.author Waśniowski, Paweł
dc.contributor.author Wędrowska, Ewelina
dc.contributor.author Golińska, Joanna
dc.contributor.author Piskorska, Elżbieta
dc.contributor.author Żukow, Walery
dc.date.accessioned 2018-01-30T11:52:45Z
dc.date.available 2018-01-30T11:52:45Z
dc.date.issued 2017-12-03
dc.identifier.citation Journal of Education, Health and Sport, No. 12, Vol. 7, pp. 412-428
dc.identifier.issn 2391-8306
dc.identifier.other doi:10.5281/zenodo.1161264
dc.identifier.uri http://repozytorium.umk.pl/handle/item/4879
dc.description.abstract Retrotransposons represent a significant part of the genome in eukaryote organisms. With DNA transposons, they belong to mobile genetic elements. There are two classes of transposons, DNA transposons and retrotransposons. Retrotransposons have three genes in their structure (gag, pol, env), responsible for the activation and encoding of structural proteins and envelope proteins. There is a group of retroelements without LTR (non-LTR). This group consists LINE (Long Interspersed Nuclear Elements) and SINE (Short Interspersed Nuclear Elements) sequences. LINE sequences represent 20% of human genetic material. Sequences of retrotransposons can move within the genome of a particular organism, occasionally subjected to replication as a result of enzyme activity, i.e. reverse transcriptase. The process of retro transposition is imperfect. These processes often cause mutation (most often: insertion, deletion), genetic instability, they contribute to the development of diseases on the genetic basis, including cancer. Retrotransposons are also used to analyze genetic variation as genetic markers.
dc.language.iso eng
dc.rights Attribution-NonCommercial-ShareAlike 4.0 International
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0
dc.subject retrotransposons
dc.subject retro transposition
dc.subject transposons
dc.subject mobile genetic elements
dc.title Mobile genetic elements – mechanism and consequences of transposition
dc.type info:eu-repo/semantics/article

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