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Enantioselective acetylation of (R,S)-atenolol: The use of Candidarugosa lipases immobilized onto magnetic chitosan nanoparticles inenzyme-catalyzed biotransformation

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dc.contributor.author Sikora, Adam
dc.contributor.author Chełminiak-Dudkiewicz, Dorota
dc.contributor.author Siódmiak, Tomasz
dc.contributor.author Tarczykowska, Agata
dc.contributor.author Sroka, Wiktor
dc.contributor.author Ziegler-Borowska, Marta
dc.contributor.author Marszałł, Michał Piotr
dc.date.accessioned 2019-05-17T10:24:58Z
dc.date.available 2019-05-17T10:24:58Z
dc.date.issued 2016
dc.identifier.citation Journal of Molecular Catalysis. B, Enzymatic, 134, 2016, pp. 43-50.
dc.identifier.issn 1381-1177
dc.identifier.uri http://repozytorium.umk.pl/handle/item/5865
dc.description.abstract tThis paper describes the enzyme immobilization protocol as well as the enzymatic method for the directresolution of (R,S)-atenolol. The used magnetic enzyme carriers possess on their surface new-synthetizedchitosan derivatives with free amine groups distanced by ethyl or butyl chain. Additionally the cat-alytic activity of two types of commercially available lipases from Candida rugosa immobilized onto twodifferent magnetic nanoparticles were compared. The highest values of enantioselectivity (E = 66.9), enan-tiomeric excess of product (eep= 94.1%) and conversion (c = 41.84%) were obtained by using lipase fromCandida rugosa OF immobilized onto Fe3O4-CS-EtNH2. The study confirmed that even after 5 reactioncycles the immobilized lipase maintain its high catalytic activity.
dc.description.sponsorship The project was supported by a research grant from theNational Science Centre,2014/15/B/NZ7/00972. Additionally, thiswork was partially supported by the National Science Centre grant2014/15/D/NZ7/01805
dc.language.iso eng
dc.rights CC0 1.0 Universal
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/publicdomain/zero/1.0/
dc.subject Enantioselective acetylation
dc.subject (R,S)-atenolol
dc.subject Magnetic nanoparticles
dc.subject Lipases
dc.title Enantioselective acetylation of (R,S)-atenolol: The use of Candidarugosa lipases immobilized onto magnetic chitosan nanoparticles inenzyme-catalyzed biotransformation
dc.type info:eu-repo/semantics/article


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