Heme oxygenase-1 induction by cobalt protoporphyrin enhances fever and inhibits pyrogenic tolerance to lipopolysaccharide

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dc.contributor.author Piotrowski, Jakub
dc.contributor.author Jędrzejewski, Tomasz
dc.contributor.author Kozak, Wiesław
dc.date.accessioned 2015-01-22T12:14:36Z
dc.date.available 2015-01-22T12:14:36Z
dc.date.issued 2014-08-19
dc.identifier.citation Journal of Thermal Biology vol. 45, 2014, pp. 69-74
dc.identifier.uri http://repozytorium.umk.pl/handle/item/2380
dc.description.abstract Heme oxygenase-1 (HO-1) is an enzyme that catalyzes degradation of the heme and regulates its availability for newly synthetized hemeproteins such as cyclooxygenases, NO synthases and cytochrome P450. Moreover, HO-1 activity modulates synthesis of cytokines and prostaglandins. All of these factors are well-defined components of fever and pyrogenic tolerance mechanisms. We examine the effect of HO-1 induction and activation using cobalt protoporphyrin (CoPP) on changes in body temperature (Tb), plasma levels of interleukin-6 (IL-6), prostaglandin E2 (PGE2) and HO-1 protein in the course of these processes. Intraperitoneally (i.p.) pre-treatment of rats with CoPP (5 mg kg?1) significantly accelerated and enhanced the early stage of lipopolysaccharide (LPS)-induced fever and shortened a post-fever recovery to normal temperature. Pre-treatment with CoPP significantly potentiated the increase in plasma IL-6, PGE2 and HO-1 levels measured 4 h after the LPS administration. Furthermore, induction of HO-1 attenuated the development of pyrogenic tolerance to repeated injections of LPS. Based on these data we conclude that heme oxygenase-1 may act as a physiological regulator of the febrile response intensity to bacterial infections.
dc.description.sponsorship The study was funded in part by the project “Step into the future-the scholarships for PhD students 3rd edition” (Grant no. 4345-1-81-3040-636/10) to J. Piotrowski, which was co-financed by the European Union within European Social Fund
dc.language.iso eng
dc.publisher Elsevier
dc.rights info:eu-repo/semantics/openAccess
dc.subject Fever
dc.subject Pyrogenic tolerance
dc.subject Lipopolysaccharide
dc.subject Interleukin-6
dc.subject Prostaglandin E2
dc.subject Heme oxygenase
dc.title Heme oxygenase-1 induction by cobalt protoporphyrin enhances fever and inhibits pyrogenic tolerance to lipopolysaccharide
dc.type info:eu-repo/semantics/article

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