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Affinity Chromatography Method for Determination of Binding of Drugs to Melanin and Evaluation of Side Effect Potential of Antipsychotic Agents

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dc.contributor.author Marszałł, Michał Piotr
dc.contributor.author Proszowska, Anna
dc.contributor.author Buciński, Adam
dc.contributor.author Kaliszan, Roman
dc.date.accessioned 2014-09-15T10:43:33Z
dc.date.available 2014-09-15T10:43:33Z
dc.date.issued 2014-09-15
dc.identifier.issn 1875-676X
dc.identifier.uri http://repozytorium.umk.pl/handle/item/2181
dc.description.abstract The extrapyramidal side effect parameters of typical and atypical antypsychotics were correlated with affinity chromatographic data determined on the melanin-based column. The chromatographic study was performed according to the hypothesis that extrapyramidal symptoms (EPS) as side effects of the use of antipsychotic drugs at clinically effective doses are correlated to the affinity of these drugs to neuromelanin. For that aim the polymerization product of L-DOPA (melanin) was immobilized onto aminopropyl silica and the binding efficiency of melanin towards antipsychotics has been determined. The results indicate that melanin based-column can be used to evaluate the risk of EPS of drug candidates to antipsychotic drug therapy.
dc.language.iso eng
dc.relation.ispartofseries Current Pharmaceutical Analysis, 2013, vol.9, s. 131-138;
dc.rights CC0 1.0 Universal
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/publicdomain/zero/1.0/
dc.subject Affinity chromatography
dc.subject drug-binding
dc.subject melanin binding
dc.subject antipsychotics
dc.subject extrapyramidal symptoms
dc.title Affinity Chromatography Method for Determination of Binding of Drugs to Melanin and Evaluation of Side Effect Potential of Antipsychotic Agents
dc.type info:eu-repo/semantics/article


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