Affinity Chromatography Method for Determination of Binding of Drugs to Melanin and Evaluation of Side Effect Potential of Antipsychotic Agents

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dc.contributor.author	Marszałł, Michał Piotr
dc.contributor.author	Proszowska, Anna
dc.contributor.author	Buciński, Adam
dc.contributor.author	Kaliszan, Roman
dc.date.accessioned	2014-09-15T10:43:33Z
dc.date.available	2014-09-15T10:43:33Z
dc.date.issued	2014-09-15
dc.identifier.issn	1875-676X
dc.identifier.uri	http://repozytorium.umk.pl/handle/item/2181
dc.description.abstract	The extrapyramidal side effect parameters of typical and atypical antypsychotics were correlated with affinity chromatographic data determined on the melanin-based column. The chromatographic study was performed according to the hypothesis that extrapyramidal symptoms (EPS) as side effects of the use of antipsychotic drugs at clinically effective doses are correlated to the affinity of these drugs to neuromelanin. For that aim the polymerization product of L-DOPA (melanin) was immobilized onto aminopropyl silica and the binding efficiency of melanin towards antipsychotics has been determined. The results indicate that melanin based-column can be used to evaluate the risk of EPS of drug candidates to antipsychotic drug therapy.
dc.language.iso	eng
dc.relation.ispartofseries	Current Pharmaceutical Analysis, 2013, vol.9, s. 131-138;
dc.rights	CC0 1.0 Universal
dc.rights	info:eu-repo/semantics/openAccess
dc.rights.uri	http://creativecommons.org/publicdomain/zero/1.0/
dc.subject	Affinity chromatography
dc.subject	drug-binding
dc.subject	melanin binding
dc.subject	antipsychotics
dc.subject	extrapyramidal symptoms
dc.title	Affinity Chromatography Method for Determination of Binding of Drugs to Melanin and Evaluation of Side Effect Potential of Antipsychotic Agents
dc.type	info:eu-repo/semantics/article