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1-ALKYL-3-METHYLIMIDAZOLIUM TETRAFLUOROBORATE AS AN ALTERNATIVE MOBILE PHASE ADDITIVES FOR DETERMINATION OF HALOPERIDOL IN PHARMACEUTICAL FORMULATION BY HPTLC UV DENSITOMETRIC METHOD

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dc.contributor.author Mieszkowski, Dominik
dc.contributor.author Siódmiak, Tomasz
dc.contributor.author Marszałł, Michał Piotr
dc.date.accessioned 2016-08-25T05:56:41Z
dc.date.available 2016-08-25T05:56:41Z
dc.date.issued 2016-08-25
dc.identifier.uri http://repozytorium.umk.pl/handle/item/3726
dc.description.abstract An alternative thin-layer chromatography (TLC) method for the determination of haloperidol in pharmaceutical formulation against the method proposed by European Pharmacopeia (7.0) has been compared and described. The proposed method uses a mobile phase composed of acetonitrile/ water, 60:40, with the addition of 1.5% (v/v) 1-ethyl-3-methylimidazolium tetrafluoroborate ionic liquid. The ionic liquid modifiers of a mobile phase have been shown to be suitable suppressor of silanol ionization in the TLC of basic drugs. Besides the silanol-suppressing potency of the 1-ethyl-3-methylimidazolium tetrafluoroborate, the lack of interaction and interference with UV densitometric detection was observed. These properties open a new possibilities in the application of alky-imidazolium-based ionic liquids in chromatographic techniques.
dc.language.iso pol
dc.rights CC0 1.0 Universal
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/publicdomain/zero/1.0/
dc.subject haloperidol
dc.subject ionic liquids
dc.subject mobile phase additives
dc.subject thin-layer chromatography
dc.title 1-ALKYL-3-METHYLIMIDAZOLIUM TETRAFLUOROBORATE AS AN ALTERNATIVE MOBILE PHASE ADDITIVES FOR DETERMINATION OF HALOPERIDOL IN PHARMACEUTICAL FORMULATION BY HPTLC UV DENSITOMETRIC METHOD
dc.type info:eu-repo/semantics/article


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