1-ALKYL-3-METHYLIMIDAZOLIUM TETRAFLUOROBORATE AS AN ALTERNATIVE MOBILE PHASE ADDITIVES FOR DETERMINATION OF HALOPERIDOL IN PHARMACEUTICAL FORMULATION BY HPTLC UV DENSITOMETRIC METHOD
| dc.contributor.author | Mieszkowski, Dominik | |
| dc.contributor.author | Siódmiak, Tomasz | |
| dc.contributor.author | Marszałł, Michał Piotr | |
| dc.date.accessioned | 2016-08-25T05:56:41Z | |
| dc.date.available | 2016-08-25T05:56:41Z | |
| dc.date.issued | 2016-08-25 | |
| dc.description.abstract | An alternative thin-layer chromatography (TLC) method for the determination of haloperidol in pharmaceutical formulation against the method proposed by European Pharmacopeia (7.0) has been compared and described. The proposed method uses a mobile phase composed of acetonitrile/ water, 60:40, with the addition of 1.5% (v/v) 1-ethyl-3-methylimidazolium tetrafluoroborate ionic liquid. The ionic liquid modifiers of a mobile phase have been shown to be suitable suppressor of silanol ionization in the TLC of basic drugs. Besides the silanol-suppressing potency of the 1-ethyl-3-methylimidazolium tetrafluoroborate, the lack of interaction and interference with UV densitometric detection was observed. These properties open a new possibilities in the application of alky-imidazolium-based ionic liquids in chromatographic techniques. | pl |
| dc.identifier.uri | http://repozytorium.umk.pl/handle/item/3726 | |
| dc.language.iso | pol | pl |
| dc.rights | CC0 1.0 Universal | * |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
| dc.subject | haloperidol | pl |
| dc.subject | ionic liquids | pl |
| dc.subject | mobile phase additives | pl |
| dc.subject | thin-layer chromatography | pl |
| dc.title | 1-ALKYL-3-METHYLIMIDAZOLIUM TETRAFLUOROBORATE AS AN ALTERNATIVE MOBILE PHASE ADDITIVES FOR DETERMINATION OF HALOPERIDOL IN PHARMACEUTICAL FORMULATION BY HPTLC UV DENSITOMETRIC METHOD | pl |
| dc.type | info:eu-repo/semantics/article | pl |