Usefulness of C-reactive protein as a marker of early post-infarct left ventricular systolic dysfunction

dc.contributor.authorŚwiątkiewicz, Iwona
dc.contributor.authorKoziński, Marek
dc.contributor.authorMagielski, Przemysław
dc.contributor.authorGierach, Joanna
dc.contributor.authorFabiszak, Tomasz
dc.contributor.authorKubica, Aldona
dc.contributor.authorSukiennik, Adam
dc.contributor.authorNavarese, Eliano Pio
dc.contributor.authorOdrowąż-Sypniewska, Grażyna
dc.contributor.authorKubica, Jacek
dc.date.accessioned2013-02-22T07:37:00Z
dc.date.available2013-02-22T07:37:00Z
dc.date.issued2012
dc.description.abstractObjective To assess the usefulness of in-hospital measurement of C-reactive protein (CRP) concentration in comparison to well-established risk factors as a marker of post-infarct left ventricular systolic dysfunction (LVSD) at discharge. Materials and methods Two hundred and four consecutive patients with ST-segment-elevation myocardial infarction (STEMI) were prospectively enrolled into the study. CRP plasma concentrations were measured before reperfusion, 24 h after admission and at discharge with an ultra-sensitive latex immunoassay. Results CRP concentration increased significantly during the first 24 h of hospitalization (2.4 ± 1.9 vs. 15.7 ± 17.0 mg/L; p\0.001) and persisted elevated at discharge (14.7 ± 14.7 mg/L), mainly in 57 patients with LVSD (2.4 ± 1.8 vs. 25.0 ± 23.4 mg/L; p\0.001; CRP at discharge 21.9 ± 18.6 mg/L). The prevalence of LVSD was significantly increased across increasing tertiles of CRP concentration both at 24 h after admission (13.2 vs. 19.1 vs. 51.5 %; p\0.0001) and at discharge (14.7 vs. 23.5 vs. 45.6 %; p\0.0001). Multivariate analysis demonstrated CRP concentration at discharge to be an independent marker of early LVSD (odds ratio of 1.38 for a 10 mg/L increase, 95 % confidence interval 1.01–1.87; p\0.04). Conclusion Measurement of CRP plasma concentration at discharge may be useful as a marker of early LVSD in patients after a first STEMI.pl
dc.identifier.citationInflammation Research vol. 61, 2012, pp. 725–734pl
dc.identifier.issn1023-3830
dc.identifier.urihttp://repozytorium.umk.pl/handle/item/382
dc.language.isoengpl
dc.publisherSpringerpl
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectacute myocardial infarctionpl
dc.subjectLeft ventricular functionpl
dc.subjectEchocardiographypl
dc.subjectC-reactive proteinpl
dc.subjectInflammationpl
dc.titleUsefulness of C-reactive protein as a marker of early post-infarct left ventricular systolic dysfunctionpl
dc.typeinfo:eu-repo/semantics/articlepl

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