Usefulness of C-reactive protein as a marker of early post-infarct left ventricular systolic dysfunction
dc.contributor.author | Świątkiewicz, Iwona | |
dc.contributor.author | Koziński, Marek | |
dc.contributor.author | Magielski, Przemysław | |
dc.contributor.author | Gierach, Joanna | |
dc.contributor.author | Fabiszak, Tomasz | |
dc.contributor.author | Kubica, Aldona | |
dc.contributor.author | Sukiennik, Adam | |
dc.contributor.author | Navarese, Eliano Pio | |
dc.contributor.author | Odrowąż-Sypniewska, Grażyna | |
dc.contributor.author | Kubica, Jacek | |
dc.date.accessioned | 2013-02-22T07:37:00Z | |
dc.date.available | 2013-02-22T07:37:00Z | |
dc.date.issued | 2012 | |
dc.description.abstract | Objective To assess the usefulness of in-hospital measurement of C-reactive protein (CRP) concentration in comparison to well-established risk factors as a marker of post-infarct left ventricular systolic dysfunction (LVSD) at discharge. Materials and methods Two hundred and four consecutive patients with ST-segment-elevation myocardial infarction (STEMI) were prospectively enrolled into the study. CRP plasma concentrations were measured before reperfusion, 24 h after admission and at discharge with an ultra-sensitive latex immunoassay. Results CRP concentration increased significantly during the first 24 h of hospitalization (2.4 ± 1.9 vs. 15.7 ± 17.0 mg/L; p\0.001) and persisted elevated at discharge (14.7 ± 14.7 mg/L), mainly in 57 patients with LVSD (2.4 ± 1.8 vs. 25.0 ± 23.4 mg/L; p\0.001; CRP at discharge 21.9 ± 18.6 mg/L). The prevalence of LVSD was significantly increased across increasing tertiles of CRP concentration both at 24 h after admission (13.2 vs. 19.1 vs. 51.5 %; p\0.0001) and at discharge (14.7 vs. 23.5 vs. 45.6 %; p\0.0001). Multivariate analysis demonstrated CRP concentration at discharge to be an independent marker of early LVSD (odds ratio of 1.38 for a 10 mg/L increase, 95 % confidence interval 1.01–1.87; p\0.04). Conclusion Measurement of CRP plasma concentration at discharge may be useful as a marker of early LVSD in patients after a first STEMI. | pl |
dc.identifier.citation | Inflammation Research vol. 61, 2012, pp. 725–734 | pl |
dc.identifier.issn | 1023-3830 | |
dc.identifier.uri | http://repozytorium.umk.pl/handle/item/382 | |
dc.language.iso | eng | pl |
dc.publisher | Springer | pl |
dc.rights | info:eu-repo/semantics/openAccess | en |
dc.subject | acute myocardial infarction | pl |
dc.subject | Left ventricular function | pl |
dc.subject | Echocardiography | pl |
dc.subject | C-reactive protein | pl |
dc.subject | Inflammation | pl |
dc.title | Usefulness of C-reactive protein as a marker of early post-infarct left ventricular systolic dysfunction | pl |
dc.type | info:eu-repo/semantics/article | pl |
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