Fabrication and characterization of new levan@CBD biocomposite sponges as potential materials in natural, non-toxic wound dressing applications

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dc.contributor.author Chełminiak-Dudkiewicz, Dorota
dc.contributor.author Machacek, Miloslav
dc.contributor.author Długaszewska, Jolanta
dc.contributor.author Wujak, Magdalena
dc.contributor.author Smolarkiewicz-Wyczachowski, Aleksander
dc.contributor.author Bocian, Szymon
dc.contributor.author Mylkie, Kinga
dc.contributor.author Gośliński, Tomasz
dc.contributor.author Marszałł, Michał Piotr
dc.contributor.author Ziegler-Borowska, Marta
dc.date.accessioned 2023-09-29T20:39:11Z
dc.date.available 2023-09-29T20:39:11Z
dc.date.issued 2023-09
dc.identifier.citation International Journal of Biological Macromolecules vol. 253, part 3, 2023
dc.identifier.other https://doi.org/10.1016/j.ijbiomac.2023.126933
dc.identifier.uri http://repozytorium.umk.pl/handle/item/6918
dc.description.abstract Wound healing is a complex process; therefore, new dressings are frequently required to facilitate it. In this study, porous bacterial levan-based sponges containing cannabis oil (Lev@CBDs) were prepared and fully characterized. The sponges exhibited a suitable swelling ratio, proper water vapor transmission rate, sufficient thermal stability, desired mechanical properties, and good antioxidant and anti-inflammatory properties. The obtained Lev@CBD materials were evaluated in terms of their interaction with proteins, human serum albumin and fibrinogen, of which fibrinogen revealed the highest binding effect. Moreover, the obtained biomaterials exhibited antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, as well as being non-hemolytic material as indicated by hemolysis tests. Furthermore, the sponges were non-toxic and compatible with L929 mouse fibroblasts and HDF cells. Most significantly, the levan sponge with the highest content of cannabis oil, in comparison to others, retained its non-hemolytic, anti-inflammatory, and antimicrobial properties after prolonged storage in a climate chamber at a constant temperature and relative humidity. The designed sponges have conclusively proven their beneficial physicochemical properties and, at the preliminary stage, biocompatibility as well, and therefore can be considered a promising material for wound dressings in future in vivo applications.
dc.description.sponsorship Narodowe Centrum Nauki UMO-2022/47/D/NZ7/01821
dc.language.iso eng
dc.publisher Elsevier
dc.rights Attribution-NoDerivs 3.0 Poland
dc.rights.uri http://creativecommons.org/licenses/by-nd/3.0/pl/
dc.subject lewan
dc.subject olejek konopny
dc.subject właściwości przeciwbakteryjne
dc.subject biokompatybilność
dc.subject materiały opatrunkowe
dc.subject Levan
dc.subject cannabis oil
dc.subject Antibacterial activity
dc.subject In vitro biocompatibility test
dc.subject Wound dressing
dc.title Fabrication and characterization of new levan@CBD biocomposite sponges as potential materials in natural, non-toxic wound dressing applications
dc.type info:eu-repo/semantics/article

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