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Ionic Liquids as Mobile Phase Additives for Feasible Assay of Naphazoline in Pharmaceutical Formulation by HPTLC–UV–Densitometric Method

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dc.contributor.author Marszałł, Michał Piotr
dc.contributor.author Sroka, Wiktor
dc.contributor.author Balinowska, Aleksandra
dc.contributor.author Mieszkowski, Dominik
dc.contributor.author Koba, Marcin
dc.contributor.author Kaliszan, Roman
dc.date.accessioned 2013-06-08T11:27:52Z
dc.date.available 2013-06-08T11:27:52Z
dc.date.issued 2013-06-08
dc.identifier.issn 1945-239X
dc.identifier.uri http://repozytorium.umk.pl/handle/item/583
dc.description.abstract A specific and reliable High-Performance Thin Layer Chromatography (HPTLC) with densitometry detection method has been developed for determination of naphazoline nitrate in nasal drops. The best separation of basic analyte, without spot tailing, was achieved using the mobile phase composed of acetonitrile:water (60:40,v/v) with 1.5 % (v/v) imidazolium-class ionic liquid added and the plates covered with stationary phase based on the RP-18 with F254S (10cm x 20cm). The presented results confirm that imidazolium tetrafluoroborate ionic liquids are efficient suppressors of free silanols, which are considered to be responsible for troublesome and irreproducible chromatographic determinations of basic compounds. The developed chromatographic system was found to be convenient in use and at the same time providing a repeatable assay of naphazoline nitrate in nasal drops, which could not be obtained with the use of standard silanol suppressing mobile phase additives, like triethylamine (TEA) or dimethyloctylamine (DMOA).
dc.language.iso eng
dc.relation.ispartofseries Journal of Chromatographic Science, 2013, 51(6), 560-565;
dc.rights CC0 1.0 Universal
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/publicdomain/zero/1.0/
dc.subject High-performance thin-layer chromatography (HPTLC)
dc.subject Ionic liquids
dc.subject Mobile phase additives
dc.subject Silanol deactivation
dc.subject Naphazoline
dc.subject Nasal drops
dc.title Ionic Liquids as Mobile Phase Additives for Feasible Assay of Naphazoline in Pharmaceutical Formulation by HPTLC–UV–Densitometric Method
dc.type info:eu-repo/semantics/article


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