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Association between ACTN3 gene polymorphism and muscle strength in older adults

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dc.contributor.author Kłoska, Sylwester
dc.contributor.author Marciniak, Anna
dc.contributor.author Woźniak, Marcin
dc.contributor.author Perkowski, Radosław
dc.contributor.author Podhorecka, Marta
dc.contributor.author Gębka, Dominika
dc.contributor.author Androsiuk-Perkowska, Joanna
dc.contributor.author Kujawski, Sławomir 
dc.contributor.author Kożuchowski, Marcin
dc.contributor.author Kozłowski, Henryk
dc.contributor.author Kędziora-Kornatowska, Kornelia
dc.contributor.author Żukow, Walery
dc.date.accessioned 2018-08-16T12:30:20Z
dc.date.available 2018-08-16T12:30:20Z
dc.date.issued 2018-07-30
dc.identifier.citation Journal of Education, Health and Sport, No. 9, Vol. 8, pp. 155-165.
dc.identifier.issn 2391-8306
dc.identifier.other doi:10.5281/zenodo.1345234
dc.identifier.uri http://repozytorium.umk.pl/handle/item/5375
dc.description.abstract The decrease of muscle strength and general physical fitness is a big problem in the elderly group. It often prevents the proper functioning of a person, which makes him/her dependent on caretakers. It is believed that the some polymorphisms in ACTN3 geneare associated with better results in strength sports. If those polymorphisms affect muscle strength, they may also be related to the health condition of older people. Our study was conducted on a group of 60 people over 60 years of age. The relationship between overall fitness and muscular strength of elderly patients with ACTN R577X gene polymorphism was checked. The ACTN3 gene was tested by PCR-RFLP. Overall fitness was tested using the IPAQ questionnaire and fitness tests: Tinetti, DGI, Up&Go, SPPB, standing on one leg (both right and left). Based on the results of the survey, the MET and BMI coefficients were determined. It was found that the RX genotype is associated with better results achieved in the SPPB test. Genotype XX was associated with worse results in the right leg standing test (p<0.05). The R-allele of the ACTN3 gene wasassociated with better results obtained during the standing test on the right leg (p<0.05).Based on obtained results it was impossible to determine a clear impact of the ACTN3 gene on muscle strength and health of the older adults.
dc.language.iso eng
dc.rights Attribution-NonCommercial-ShareAlike 4.0 International
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject sport geneticsł ACTN3ł older adultsł geriatric patient
dc.title Association between ACTN3 gene polymorphism and muscle strength in older adults
dc.type info:eu-repo/semantics/article


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