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Drug-coated balloons in treatment of in-stent restenosis: a meta-analysis of randomised controlled trials

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dc.contributor.author Navarese, Eliano Pio
dc.contributor.author Austin, David
dc.contributor.author Gurbel, Paul Alfred
dc.contributor.author Andreotti, Felicita
dc.contributor.author Tantry, Udaya S.
dc.contributor.author James, Stefan
dc.contributor.author Buffon, Antonino
dc.contributor.author Koziński, Marek
dc.contributor.author Obońska, Karolina
dc.contributor.author Bliden, Kevin P.
dc.contributor.author Jeong, Young-Hoon
dc.contributor.author Kubica, Jacek
dc.contributor.author Kunadian, Vijay
dc.date.accessioned 2013-04-17T12:13:10Z
dc.date.available 2013-04-17T12:13:10Z
dc.date.issued 2013-04-17
dc.identifier.citation Clinical Research in Cardiology vol. 102(4), 2012, pp.:279-287.
dc.identifier.issn 1861-0692
dc.identifier.uri http://repozytorium.umk.pl/handle/item/491
dc.description.abstract Background Drug-coated balloons (DCBs) have been developed for the percutaneous treatment of coronary artery disease. An initial focus has been the management of in-stent restenosis (ISR) but randomised controlled trials (RCTs) have been small and powered only for angiographic endpoints. Objective The aim of the work was to assess the clinical and angiographic outcomes of patients treated for ISR with DCB versus control (balloon angioplasty or drug-eluting stents) by a meta-analysis of RCTs. Methods A comprehensive search was performed of RCTs where patients with ISR were randomly assigned to either DCB or alternative coronary intervention. Outcome measurements were death, myocardial infarction (MI), target lesion revascularisation (TLR), binary definition of restenosis and in-lesion late luminal loss (LLL). Results Four studies were identified that fulfilled the inclusion criteria. Pooled odds ratios (ORs) were calculated for patients treated for ISR (n = 399). Mean follow-up duration was 14.5 months. DCBs were associated with lower rates of TLR [8.8 vs. 29.7 % OR (95 % confidence interval, CI) 0.20 (0.11–0.36), p\0.0001], binary restenosis [10.3 vs. 41.3 % OR (95 % CI) 0.13 (0.07–0.24), p\0.00001] and MI [0.5 vs. 3.8 %, OR (95 % CI) 0.21 (0.04–1.00), p = 0.05]. No significant heterogeneity was identified. Conclusion Drug-coated balloons appear to be effective versus control in reducing TLR and possibly MI versus balloon angioplasty or drug-eluting stents in the management of ISR.
dc.language.iso eng
dc.rights info:eu-repo/semantics/openAccess
dc.subject Coronary artery disease
dc.subject Angioplasty
dc.subject Drug-coated balloons
dc.subject Drug-eluting stents
dc.subject Meta-analysis
dc.subject Randomized controlled trials
dc.title Drug-coated balloons in treatment of in-stent restenosis: a meta-analysis of randomised controlled trials
dc.type info:eu-repo/semantics/article


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