Synthesis and application of (18F) fluorodeoxyglucose in oncology diagnosis

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dc.contributor.author Wędrowski, Mateusz
dc.contributor.author Waśniowski, Paweł
dc.contributor.author Wędrowska, Ewelina
dc.contributor.author Piskorska, Elżbieta
dc.contributor.author Czuczejko, Jolanta
dc.contributor.author Małkowski, Bogdan
dc.contributor.author Żukow, Walery
dc.date.accessioned 2018-02-05T13:52:04Z
dc.date.available 2018-02-05T13:52:04Z
dc.date.issued 2017-12-31
dc.identifier.citation Journal of Education, Health and Sport 7 (12), 481-500.
dc.identifier.issn 2391-8306
dc.identifier.other http://dx.doi.org/10.5281/zenodo.1164181
dc.identifier.uri http://repozytorium.umk.pl/handle/item/4884
dc.description.abstract [18F] Fluorodeoxyglucose ([18F] FDG) is the most commonly used radiopharmaceutical in clinical positron emission tomography (PET) in oncology. Cancer cells create their own specific microenvironment to survive and grow. Specific tumor microenvironment contributes to cancer metabolic reprogramming. Therefore, even with sufficient oxygen availability, cancer cells choose anaerobic glycolysis. Cancer cells compensate less energy efficient process by increasing the intensity of anaerobic glycolysis. Tumor cells have a high rate of metabolism and because of this, they take up more of the radioactive glucose (FDG). This makes the tumor cells appear more visible than other areas on the PET scan pictures. This paper presents nucleophilic synthesis of the [18F] FDG marker and basics of tumor development which can affect the [18F] FDG biochemical significance. Reference was made to clinical images obtained in PET technology using the [18F] FDG radiopharmaceutical.
dc.language.iso eng
dc.rights Attribution-NonCommercial-ShareAlike 3.0 Poland
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/pl/
dc.subject synthesis [18F] FDG
dc.subject glucose metabolism
dc.subject [18F] FDG metabolism
dc.subject positron emission tomography
dc.title Synthesis and application of (18F) fluorodeoxyglucose in oncology diagnosis
dc.type info:eu-repo/semantics/article

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