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Enantioseparation of (RS)-atenolol with the use of lipases immobilized onto new-synthesized magnetic nanoparticles

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dc.contributor.author Sikora, Adam
dc.contributor.author Chełminiak-Dutkiewicz, Dorota
dc.contributor.author Ziegler-Borowska, Marta
dc.contributor.author Marszałł, Michał Piotr
dc.date.accessioned 2017-04-21T08:11:23Z
dc.date.available 2017-04-21T08:11:23Z
dc.date.issued 2017-04-21
dc.identifier.uri http://repozytorium.umk.pl/handle/item/4308
dc.description.abstract The enzymatic method was used for the direct resolution of racemic atenolol. The catalytic activities of commercially available lipases from Candida rugosa (MY and OF) immobilized onto new-synthesized chitosan magnetic nanoparticles [Fe3O4-CS-Et(NH2)2, Fe3O4-CS-Et(NH2)3] in the kinetic resolution of racemic atenolol were compared. The best results were obtained by using Candida rugosa lipase OF immobilized onto Fe3O4-CS-Et(NH2)3. Additionally, the enzyme reusability was investigated. It was established that even after 5 reaction cycles, both lipases from Candida rugosa maintained their high catalytic activities and operational stabilities. This approach is extremely important from an economical point of view, because it allows for a direct cost reduction of the biotransformation.
dc.language.iso pol
dc.rights CC0 1.0 Universal
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/publicdomain/zero/1.0/
dc.subject enantioseparation of (RS)-atenolol
dc.subject magnetic particles
dc.subject lipase
dc.title Enantioseparation of (RS)-atenolol with the use of lipases immobilized onto new-synthesized magnetic nanoparticles
dc.type info:eu-repo/semantics/article


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