Home

Value of C-Reactive Protein as a Risk Factor for Acute Coronary Syndrome: A Comparison with Apolipoprotein Concentrations and Lipid Profile

Repository of Nicolaus Copernicus University

Show simple item record

dc.contributor.author Krintus, Magdalena
dc.contributor.author Koziński, Marek
dc.contributor.author Stefańska, Anna
dc.contributor.author Sawicki, Marcin
dc.contributor.author Obońska, Karolina
dc.contributor.author Fabiszak, Tomasz
dc.contributor.author Kubica, Jacek
dc.contributor.author Sypniewska, Grażyna
dc.date.accessioned 2013-02-22T07:45:27Z
dc.date.available 2013-02-22T07:45:27Z
dc.date.issued 2012
dc.identifier.citation Mediators of Inflammation vol. 2012 (2012), Article ID 419804, 10 pages
dc.identifier.issn 1466-1861
dc.identifier.uri http://repozytorium.umk.pl/handle/item/383
dc.description.abstract Objective. To investigate whether assessment of C-reactive protein (CRP) and apolipoproteins, besides the traditional lipid profile, enhances the assessment process for the risk of acute coronary syndrome (ACS). Methods. The study group consisted of 220 consecutive patients admitted to hospital within the first 6 hours from the onset of chest pain. Patients were diagnosed with unstable angina (n = 96), non-ST-elevation myocardial infarction (NSTEMI; n = 57), or ST-elevation myocardial infarction (STEMI; n = 67). ACS patients were compared with 116 healthy volunteers in a case-control study. The serum was assayed on admission for CRP, apolipoproteins ApoAI and ApoB100, and lipid parameters. Results. The highest concentrations of CRP were found in NSTEMI and STEMI, with a median value four-fold higher in ACS patients than in controls (P < 0.0001). Only CRP significantly increased the probability of ACS development (adjusted odds ratio for a 1 mg/L increase 1.90; 95% confidence interval [CI] 1.34–2.89) and explained 90% of the variation for ACS development. Similarly, we demonstrated the highest diagnostic accuracy for CRP among all investigated markers (area under the curve 0.80; 95% CI 0.75–0.85). Conclusions. Our study indicates that CRP superiorly to apolipoproteins and lipid profile facilitates the risk stratification for ACS occurrence.
dc.language.iso eng
dc.publisher Hindawi Publishing Corporation
dc.rights info:eu-repo/semantics/openAccess
dc.subject C-Reactive Protein
dc.subject acute coronary syndrome
dc.subject Apolipoprotein Concentrations
dc.subject Lipid Profile
dc.title Value of C-Reactive Protein as a Risk Factor for Acute Coronary Syndrome: A Comparison with Apolipoprotein Concentrations and Lipid Profile
dc.type info:eu-repo/semantics/article


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search repository



Advanced Search

Browse

My Account

Statistics

Informations