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Polymorphism of the glutathione S-transferases in prostate cancer

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dc.contributor.author Dróżdż, Joanna
dc.contributor.author Bombolewska, Karolina
dc.contributor.author Kamiński, Piotr
dc.contributor.author Bogdzińska, Maria
dc.date.accessioned 2016-06-20T12:06:29Z
dc.date.available 2016-06-20T12:06:29Z
dc.date.issued 2013-08-14
dc.identifier.citation Copernican Letters, Vol. 4, pp. 17-22
dc.identifier.issn 2082-968X
dc.identifier.other doi:10.12775/CL.2013.002
dc.identifier.uri http://repozytorium.umk.pl/handle/item/3491
dc.description.abstract Prostate cancer occurs more and more frequently in men over 50 years of age. Its etiology is still unclear, despite numerous studies of its main risk factors. Scientists discovered, that it  is genetically and environmentally determined. Recent publications suggest the role of S-glutathione transferases (GSTs) in modulation of prostate cancer risk. Numerous studies try to reveal the role of three the best known genetic variants, GSTM1, GSTT1 and GSTP1. Glutathione S-transferases as a multi-family of metabolic enzymes of the II-phase, are responsible for detoxification of various, potentially carcinogenic compounds. Deficiencies or changed activity of the enzymes, may increase the risk of mutation. The GSTs could be important  in the etiology of cancers, including prostate cancer. Numerous study suggest the influence of GSTM1, GSTT1 and GSTP1 polimorphisms on susceptibility to prostate cancer, while others, exclude such correlation. Therefore determining the significance of these genetic variants in prostate cancer  should be the subject of further extensive research.
dc.language.iso eng
dc.rights Attribution-NoDerivs 3.0 Poland
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nd/3.0/pl/
dc.subject Glutathione Transferase
dc.subject Prostatic Neoplasms
dc.subject Metabolic Detoxication, Phase II
dc.title Polymorphism of the glutathione S-transferases in prostate cancer
dc.type info:eu-repo/semantics/article


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