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Putative neuroprotective role of visfatin against cognitive dysfunction in obese patients

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dc.contributor.author Bieliński, Maciej
dc.contributor.author Tomaszewska, Marta
dc.contributor.author Pulkowska-Ulfig, Joanna
dc.contributor.author Sikora, Marcin
dc.contributor.author Tretyn, Andrzej
dc.contributor.author Kamińska, Anna
dc.contributor.author Kopczyńska, Ewa
dc.contributor.author Junik, Roman
dc.contributor.author Borkowska, Alina
dc.date.accessioned 2015-08-04T07:07:30Z
dc.date.available 2015-08-04T07:07:30Z
dc.date.issued 2014-12
dc.identifier.citation Indian Journal of Research (Physical Education) vol. 3 (12), 2014, pp. 149-152.
dc.identifier.issn 2250-1991
dc.identifier.uri http://repozytorium.umk.pl/handle/item/2909
dc.description.abstract Objectives: Visfatin (adipokine) is thought to have neuroprotective properties. The aims of to determine the type and extent of prefrontal cortical dysfunction and to evaluate the potential neuroprotective role of visfatin. Methods: Sixty-one obese patients were included. A diagnosis of primary obesity was made on the basis of a BMI > 30. Visfatin serum levels were determined by enzyme immunoassay. The Wisconsin Card Sorting Test (WCST) was used to assess prefrontal cortex-mediated cognitive function. Results: Visfatin levels were not correlated with age or BMI. However, patients with higher visfatin levels tended to show an overall improvement in WCST scores. Nonetheless, a significant positive correlation (P = 0.032) was found only between high serum visfatin levels and the number of correctly completed categories in the WCST. Discussion: The results described herein indicate a possible neuroprotective effect of visfatin against obesity-related cognition dysfunction, particularly in regard to the categorizing capacity associated with executive function.
dc.language.iso eng
dc.publisher PARIPEX
dc.rights Attribution-NonCommercial-NoDerivs 3.0 Poland
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/pl/
dc.subject cognition
dc.subject obesity
dc.subject visfatin
dc.title Putative neuroprotective role of visfatin against cognitive dysfunction in obese patients
dc.type info:eu-repo/semantics/article


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