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The evaluation of the impact of titania nanotube covers morphology and crystal phase on their biological properties

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dc.contributor.author Lewandowska, Żaneta
dc.contributor.author Piszczek, Piotr
dc.contributor.author Radtke, Aleksandra
dc.contributor.author Jędrzejewski, Tomasz
dc.contributor.author Kozak, Wiesław
dc.contributor.author Sadowska, Beata
dc.date.accessioned 2015-03-20T10:42:10Z
dc.date.available 2015-03-20T10:42:10Z
dc.date.issued 2015-03-20
dc.identifier.uri http://repozytorium.umk.pl/handle/item/2641
dc.description.abstract The highly ordered titanium dioxide nanotube coatings were produced under various electrochemical conditions on the surface of titanium foil. The anodization voltage changes proved to be a main factor which directly affects the nanotube morphology, structure, and wettability. Moreover we have noticed a significant dependence between the size and crystallinity of TiO 2 layers and the adhesion/ proliferation of fibroblasts and antimicrobial properties. Cellular functionality were investigated for up to 3 days in culture using a cell viability assay and scanning electron microscopy. In general, results of our studies revealed that fibroblasts adhesion, proliferation, and differentiation on the titania nanotube coatings is clearly higher than on the surface of the pure titanium foil. The formation of crystallic islands in the nanotubes structure induced a significant acceleration in the growth rate of fibroblasts cells by as much as *200 %. Additionally, some types of TiO 2 layers revealed the ability to the reduce of the staphylococcal aggregates/biofilm formation. The nanotube coatings formed during the anodiza-tion process using the voltage 4 V proved to be the stronger S. aureus aggregates/biofilm inhibitor in comparison to the uncovered titanium substrate. That accelerated eukaryotic cell growth and anti-biofilm activity is believed to be advantageous for faster cure of dental and orthopaedic patients , and also for a variety of biomedical diagnostic and therapeutic applications.
dc.language.iso eng
dc.rights info:eu-repo/semantics/openAccess
dc.subject nanotechnologia
dc.subject nanorurki
dc.title The evaluation of the impact of titania nanotube covers morphology and crystal phase on their biological properties
dc.type info:eu-repo/semantics/article


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