Aptamers in Diagnostics and Treatment of Viral Infections

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dc.contributor.author Wandtke, Tomasz
dc.contributor.author Woźniak, Joanna
dc.contributor.author Kopiński Piotr
dc.date.accessioned 2015-02-23T09:23:47Z
dc.date.available 2015-02-23T09:23:47Z
dc.date.issued 2015-02-16
dc.identifier.citation Viruses 2015, 7, 751-780, doi:10.3390/v 7020751
dc.identifier.issn 1999-4915
dc.identifier.uri http://repozytorium.umk.pl/handle/item/2603
dc.description.abstract Aptamers are in vitro selected DNA or RNA molecules that are capable of binding a wide range of nucleic and non-nucleic acid molecules with high affinity and specificity. They have been conducted through the process known as SELEX (Systematic Evolution of Ligands by Exponential Enrichment). It serves to reach specificity and considerable affinity to target molecules, including those of viral origin, both proteins and nucleic acids. Properties of aptamers allow detecting virus infected cells or viruses themselves and make them competitive to monoclonal antibodies. Specific aptamers can be used to interfere in each stage of the viral replication cycle and also inhibit its penetration into cells. Many current studies have reported possible application of aptamers as a treatment or diagnostic tool in viral infections, e.g., HIV (Human Immunodeficiency Virus), HBV (Hepatitis B Virus), HCV (Hepatitis C Virus), SARS (Severe Acute Respiratory Syndrome), H5N1 avian influenza and recently spread Ebola. This review presents current developments of using aptamers in the diagnostics and treatment of viral diseases.
dc.description.sponsorship Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy
dc.language.iso eng
dc.publisher MDPI
dc.rights Attribution 3.0 Poland
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/3.0/pl/
dc.subject aptamer
dc.subject SELEX
dc.subject HIV
dc.subject HCV
dc.subject H5N1
dc.subject HSV
dc.subject HPV
dc.subject Ebola
dc.title Aptamers in Diagnostics and Treatment of Viral Infections
dc.type info:eu-repo/semantics/article

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